Are macrolides now obligatory in severe community-acquired pneumonia?
نویسندگان
چکیده
منابع مشابه
Severe community-acquired pneumonia.
Community-acquired pneumonia (CAP) is the leading cause of death from infectious diseases in the United States. It accounts for 500,000 hospitalizations and 45,000 deaths each year, and it represents one of the most common causes of ICU admission. The mortality rate due to severe CAP has shown little improvement over the past few years, with rates as high as 58% when patients were admitted to t...
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Combination therapy with two antimicrobial agents is superior to monotherapy in severe community-acquired pneumonia, and recent data suggest that addition of a macrolide as the second antibiotic might be superior to other combinations. This observation requires confirmation in a randomised control trial, but this group of antibiotics have pleiotropic effects that extend beyond bacterial killing...
متن کاملMiddle molecules in severe community-acquired pneumonia
Results Patients admitted had mean age of 62 ± 1.2 years, PORT classes IV-V and mean Pneumonia Severity Index score of 108.5 ± 3.8. In all patients on admission there was a high level of endogenous intoxication manifested by 1.8 times increasing levels of MM compared to the control group (0.262 ± 0.001 versus 0.146 ± 0.02 optic units, p < 0.05). There was a positive trend with a decline of MM o...
متن کامل[Severe community-acquired pneumonia in adults].
Patients with severe community acquired pneumonia (CAP) need continuous surveillance and monitoring at intensive care units (ICU), where they can receive specialized support as mechanical ventilation and/or hemodynamic support. Patients that require ICU admittance represent 10 to 30% of all patients interned because a pneumonia. In this category, high complication rate, prolonged hospital stay ...
متن کاملNovel biomarkers in severe community-acquired pneumonia.
Community-acquired pneumonia (CAP) is the most common infectious disease requiring admission to intensive care units (ICUs), and achieving an early and precise diagnosis of CAP remains a challenge. Biomarkers play an important role in improving clinical judgment in the emergency room and are adjuvant in evaluating treatment responses. Novel biomarkers, such as cortisol, pro-adrenomedullin and e...
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ژورنال
عنوان ژورنال: Intensive Care Medicine
سال: 2009
ISSN: 0342-4642,1432-1238
DOI: 10.1007/s00134-009-1734-7